Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 May;33(3):375-80.

Heterozygote advantage in Tay-Sachs carriers?

B Spyropoulos, P B Moens, J Davidson, J A Lowden

Heterozygote advantage in Tay-Sachs carriers?

B Spyropoulos et al. Am J Hum Genet. 1981 May.

Abstract

Chi-square analyses of new data as well as data previously reported by Myrianthopoulos have shown that grandparents of Tay-Sachs carriers die from proportionally the same causes as grandparents of noncarriers. It is unlikely that there is any advantage to being a Tay-Sachs carrier insofar as resistance to tuberculosis is concerned. Our results are further evidence to support Fraikor's claim that the high carrier frequency of the allele in Ashkenazi Jews is probably caused by a combination of founder effect, genetic drift, and differential immigration patterns.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Am J Hum Genet. 1972 May;24(3):339-40 - PubMed
    1. Am J Hum Genet. 1972 May;24(3):341-2 - PubMed
    1. Can Med Assoc J. 1974 Aug 3;111(3):229-33 - PubMed
    1. Soc Biol. 1977 Summer;24(2):117-34 - PubMed
    1. Prog Clin Biol Res. 1977;18:95-106 - PubMed

Publication types

LinkOut - more resources