Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 May;33(3):421-31.

A new genetic model proposing that the Se gene is a structural gene closely linked to the H gene

R Oriol, J Danilovs, B R Hawkins

A new genetic model proposing that the Se gene is a structural gene closely linked to the H gene

R Oriol et al. Am J Hum Genet. 1981 May.

Abstract

The Se gene is classically considered as a regulatory gene controlling the expression of the structural gene H in external secretions. Under this hypothesis, Bombay (h/h) individuals should not be able to express the Se gene. Statistical analysis of the 44 published Bombay pedigrees suggests on the contrary that there is no suppression of Se in Bombay individuals, and that both Se and H loci can be fully expressed at the phenotypic level. Based on a lod score of 12.9 at 1% recombination units and the existence of two different acceptors for the biosynthesis of the H antigen, a new genetic model is proposed in which H and Se would be two closely linked structural genes coding for two different 2-alpha-L-fucosyltransferases.

PubMed Disclaimer

References

    1. Eur J Biochem. 1972 Oct;30(2):269-77 - PubMed
    1. Am J Clin Pathol. 1962 Jun;37:579-83 - PubMed
    1. Lancet. 1952 May 3;1(6714):903-4 - PubMed
    1. Vox Sang. 1968;15(5):353-66 - PubMed
    1. Vox Sang. 1969 Mar;16(3):179-82 - PubMed

Publication types

LinkOut - more resources