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. 1981 Jun;40(3):245-9.
doi: 10.1136/ard.40.3.245.

Acute adverse reactions attributed to allopurinol in hospitalised patients

G T McInnes, D H Lawson, H Jick

Acute adverse reactions attributed to allopurinol in hospitalised patients

G T McInnes et al. Ann Rheum Dis. 1981 Jun.

Abstract

Of 29 524 hospitalised medical patients monitored in a drug surveillance programme 1835 (6.2%) received the xanthine oxidase inhibitor allopurinol. After the exclusion of skin reactions adverse effects were attributed to this drug in 33 (1.8%) patients, the most frequent being haematological abnormalities (11 patients, 0.6%) and diarrhoea and drug fever (5 each, 0.3%). Adverse effects were dose-related. Reactions were unrelated to age, weight, reason for therapy, admission blood urea, or albumin concentrations. Acute exacerbation of gout was troublesome in 3 patients (1 in 600 exposed).

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