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. 1981 Jun;43(6):767-71.
doi: 10.1038/bjc.1981.114.

Plasma prostaglandins in mucositis due to radiotherapy and chemotherapy for head and neck cancer

N S Tanner, I F Stamford, A Bennett
Free PMC article

Plasma prostaglandins in mucositis due to radiotherapy and chemotherapy for head and neck cancer

N S Tanner et al. Br J Cancer. 1981 Jun.
Free PMC article

Abstract

Patients with head and neck cancer were treated with synchronous radiotherapy and chemotherapy (vincristine, bleomycin and methotrexate). Before treatment, mucositis was absent and low amounts of prostaglandin-like material were extracted from peripheral plasma. As treatment proceeded mucositis occurred, and its degree correlated with the amount of prostaglandin-like material extracted from the plasma. Some patients were given moderate doses of drugs which inhibit prostaglandin synthesis, but mucositis still occurred.

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