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. 1981 Jul;73(3):787-9.
doi: 10.1111/j.1476-5381.1981.tb16816.x.

Theophylline does not affect morphine inhibition of the isolated vas deferens

T W Stone

Theophylline does not affect morphine inhibition of the isolated vas deferens

T W Stone. Br J Pharmacol. 1981 Jul.

Abstract

1 Adenosine and morphine both produced an inhibition of the electrically-evoked twitch of the isolated superfused vas deferens of the mouse. 2 Theophylline, 10 or 100 muM, reduced the inhibitory action of adenosine but did not change inhibition by morphine. 3 It is suggested that adenosine release is not a necessary prerequisite for morphine inhibition of transmitter release. It is also suggested that the involvement of adenosine may follow activation only by opiate mu-receptors.

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