Immune response genes in chickens: the multifarious responsiveness to (T,G)-A--L
- PMID: 72494
- DOI: 10.1007/978-1-4613-4169-7_22
Immune response genes in chickens: the multifarious responsiveness to (T,G)-A--L
Abstract
Immune response in chickens to the multichain copolymer (T,G)-A--L 2030 is analysed. Previous work has shown that responsiveness is not linked to the B-complex. Three different antibody specificities could be distinguished. From the data it is proposed that the response to the backbone of (T,G)-A--L (poly-DL-alanine) influences the responses to the side chain determinants (primarily the (T,G)-determinant). Thus the anti-(T,G) response in chickens is determined by at least two different loci, the B-complex, and another, as yet unidentified locus which determines the response to the poly-DL-alanine determinant. A third antibody specificity is directed against G-A--L and is only detectable in chickens which are high responders to poly-DL-alanine.
Similar articles
-
Identification of different antigenic determinants within the synthetic multichain co-polymer poly(Tyr,Glu)-polyAla--polyLys as recognized by the chicken. I. Significance of the polyAla--polyLys backbone and identification of poly-D-alanine as the antigenic determinant in backbone-directed responses.Scand J Immunol. 1977;6(1-2):31-8. doi: 10.1111/j.1365-3083.1977.tb00320.x. Scand J Immunol. 1977. PMID: 66738
-
Identification of different antigenic determinants within the synthetic multichain Co-polymer poly(LTyr,LGlu)-poly(DLAla) -- poly (LLys), (T,G)-A--L, as recognized by the chicken. II. Fine-specificities of the anti-(T,G) part of chicken anti-(T,G)-A--L antisera.Scand J Immunol. 1978;8(4):303-12. doi: 10.1111/j.1365-3083.1978.tb00523.x. Scand J Immunol. 1978. PMID: 82272
-
Antibody response of inbred mouse strains to ordered tetrapeptides of tyrosine and glutamic acid attached to multichain polyalanine or polyproline. Tyr-Tyr-Glu-Glu is a major determinant of the random poly-(Tyr, Glu)-polyDLAla--polyLys.J Exp Med. 1974 Aug 1;140(2):349-55. doi: 10.1084/jem.140.2.349. J Exp Med. 1974. PMID: 4136183 Free PMC article.
-
The nature and functions of specific immune response genes and their products.Adv Exp Med Biol. 1978;98:429-46. doi: 10.1007/978-1-4615-8858-0_25. Adv Exp Med Biol. 1978. PMID: 102129
-
B-complex genetic control of immune response to HSA, (T,G)-A--L, GT and other substances in chickens.J Immunogenet. 1979 Dec;6(6):453-60. doi: 10.1111/j.1744-313x.1979.tb00700.x. J Immunogenet. 1979. PMID: 118224
Cited by
-
Structure and properties of the major histocompatibility complex of the chicken. Speculations on the advantages and evolution of polymorphism.Immunogenetics. 1981;13(1-2):1-23. doi: 10.1007/BF00524601. Immunogenetics. 1981. PMID: 6262224 Review. No abstract available.