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. 1977:88:233-43.
doi: 10.1007/978-1-4613-4169-7_22.

Immune response genes in chickens: the multifarious responsiveness to (T,G)-A--L

C Koch, K Hála, P Sorup

Immune response genes in chickens: the multifarious responsiveness to (T,G)-A--L

C Koch et al. Adv Exp Med Biol. 1977.

Abstract

Immune response in chickens to the multichain copolymer (T,G)-A--L 2030 is analysed. Previous work has shown that responsiveness is not linked to the B-complex. Three different antibody specificities could be distinguished. From the data it is proposed that the response to the backbone of (T,G)-A--L (poly-DL-alanine) influences the responses to the side chain determinants (primarily the (T,G)-determinant). Thus the anti-(T,G) response in chickens is determined by at least two different loci, the B-complex, and another, as yet unidentified locus which determines the response to the poly-DL-alanine determinant. A third antibody specificity is directed against G-A--L and is only detectable in chickens which are high responders to poly-DL-alanine.

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