[Trans-placental transfer of four anti-inflammatory agents. A study carried out by in vitro perfusion (author's transl)]

Abstract

Phenylbutazone, oxyphenylbutazone, ketoprofene and indocid transfer through the placenta (TFp) were studied by perfusing a placental cotyledon at term in vitro. These drugs were used in the therapeutic doses that are employed in human clinical practice. Antipyrine was used as a control material to check the validity of the perfusion in each experiment. TFp of phenylbutazone was 25.83 per cent +/- 0.46, of oxyphenylbutazone 22.48 per cent +/- 1.38, of ketoprofene 35.574 per cent +/- 0.95 and of indomethacin 36.19 per cent +/- 0.26. The authors point out the advantages and the possible dangers of non-steroid anti-inflammatory agents used in pregnant women. They prefer the use of ketoprofene of indomethacin because the anti-prostaglandin properties of ketoprofene are greater although the TFp is significantly less.