Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Mar 1;153(3):694-705.
doi: 10.1084/jem.153.3.694.

Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae

D E Briles, M Nahm, K Schroer, J Davie, P Baker, J Kearney, R Barletta

Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae

D E Briles et al. J Exp Med. .

Abstract

The antiphosphocholine (PC) antibody in normal mouse sera (NMS) provides protection against intravenous infection with encapsulated strain WU2 of type 3 Streptococcus pneumoniae. Mice unable to make anti-PC antibody, as a result of suppression with anti-T-15 idiotype or inheritance of the xid gene of CAB/N mice, are highly susceptible to infection with strain WU2. Mice inheriting the xid gene can be protected with NMS from immunologically normal mice or with IgM hybridoma anti-PC antibody. The protective effect of NMS can be removed with PC-containing immunoabsorbents.

PubMed Disclaimer

References

    1. J Immunol. 1978 Jul;121(1):371-6 - PubMed
    1. Infect Immun. 1976 Mar;13(3):750-7 - PubMed
    1. Cell. 1980 Mar;19(3):617-25 - PubMed
    1. J Exp Med. 1938 Apr 30;67(5):799-808 - PubMed
    1. Biochem J. 1968 Dec;110(3):573-82 - PubMed

Publication types