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Comparative Study
. 1981 May;11(3):193-5.
doi: 10.1007/BF01967613.

The direct excitatory effects of cimetidine on the smooth muscle of guinea pig ileum

S Vyas, S C Verma
Comparative Study

The direct excitatory effects of cimetidine on the smooth muscle of guinea pig ileum

S Vyas et al. Agents Actions. 1981 May.

Abstract

1. Cimetidine produced dose-dependent contractions in isolated guinea pig ileum and these responses were not blocked by mepyramine the H1-receptor antagonist. 2. Atropine competitively inhibited the cimetidine-induced contractions in the guinea pig ileum. 3. Cimetidine-induced responses were potentiated in the presence of eserine. Magnesium ions non-competitively inhibited the contractions due to cimetidine. Our findings suggest that cimetidine excites the guinea pig ileum through muscarinic receptors by releasing acetylcholine.

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