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. 1981 Aug;40(4):360-5.
doi: 10.1136/ard.40.4.360.

Circulating immune complexes in polymyalgia rheumatica and giant cell arteritis

J R Park, J G Jones, G D Harkiss, B L Hazleman

Circulating immune complexes in polymyalgia rheumatica and giant cell arteritis

J R Park et al. Ann Rheum Dis. 1981 Aug.

Abstract

Sera from patients with giant cell arteritis and/or polymyalgia rheumatica have been found to contain increased levels of circulating immune complexes (IC). Results with the polyethyleneglycol precipitation complement consumption (PEG-CC) assay have been correlated with disease activity. 44% of samples from an active untreated group (21 patients) had increased levels of ICs compared with 23% from an inactive treated group (49 patients). Further analysis of circulating ICs was performed by 125I-Clq binding, the PEG-C4 test, and 125I-conglutinin binding assays. Although we did not find a high correlation between IC levels and disease activity, isolation and analysis of the ICs may lead to further understanding of this disorder.

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