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. 1978 Sep-Oct;50(5):573-5.

[Metabolism of homocarnosine and gamma-amino butyric acid in different regions of rat brain under hyperoxia]

[Article in Russian]
T I Bondarenko, A A Krichevskaia, V S Shugaleĭ
  • PMID: 726092

[Metabolism of homocarnosine and gamma-amino butyric acid in different regions of rat brain under hyperoxia]

[Article in Russian]
T I Bondarenko et al. Ukr Biokhim Zh (1978). 1978 Sep-Oct.

Abstract

The content of homocarnosine, GAMA, histidine, glutaminic acid and activity of glutamate decarboxylase were studied in four regions of rats brain: cerebral hemispheres, midbrain, diencephalon and cerebellum, in norm and under hyperoxia. A considerable decrease in the content of homocarnosine, GAMA and histidine is observed in all the studied regions of the rat brain in the convulsion stage of oxygen poisoning. A decrease in the glutamate decarboxylase activity is the reason for a drop in the GAMA content. Homocarnosine in the brain is bound functionally with the GAMA level.

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