Alterations in local glucose consumption following systemic administration of kainic acid, bicuculline or metrazol

Abstract

Using the autoradiographic deoxyglucose method, local consumption of glucose has been visualized during convulsive seizures induced by systemic administration of kainic acid, bicuculline or metrazol. A striking correlation was found between the time course of the electrographic and metabolic alterations in limbic structures following kainic acid administration. In addition, pathological alterations were almost exclusively observed in structures in which there had been a rise in metabolism. In contrast, following bicuculline or metrazol a rise in metabolism was conspicuous primarily in the cerebellum, vestibular nuclei and neocortex.