The effect of intragastric pressure on gastric blood flow after partial devascularization of the stomach in cats

Abstract

The influence of intragastric pressure (IGP) on gastric blood flow was studied in cats with regional ischemia due to partial gastric devascularization, and in sham-operated cats. IGP was controlled by intragastric installation of saline. Blood flow was determined by means of the microsphere distribution technique. Increment of IGP reduced mucosal and muscularis blood flow in all areas of the stomach, both in sham-operated and devascularized cats. In areas with reduced mucosal blood flow due to devascularization, blood flow became further reduced by IGP to an extremely low flow level. The present results are pertinent to the pathogenesis of early lesser curvature ulcer or necrosis sometimes ll areas of the stomach, both in sham-operated and devascularized cats. In areas with reduced mucosal blood flow due to devascularization, blood flow became further reduced by IGP to an extremely low flow level. The present results are pertinent to the pathogenesis of early lesser curvature ulcer or necrosis sometimes ll areas of the stomach, both in sham-operated and devascularized cats. In areas with reduced mucosal blood flow due to devascularization, blood flow became further reduced by IGP to an extremely low flow level. The present results are pertinent to the pathogenesis of early lesser curvature ulcer or necrosis sometimes occurring after proximal gastric vagotomy in man.