[Interval treatment with local corticosteroids and bases]

Abstract

Three therapy models under the application of fluocinolone acetonide 0.025% (Jellin) were compared with each other. Conventional therapy: application of Jellin ointment or cream alone, n = 24; daily interval therapy: alternating application (morning and evening) of Jellin ointment or cream and their bases, n = 26; weekly interval therapy: application of Jellin ointment or cream for 4 days followed by a 3-day application of the corresponding base, n = 21. 71 patients participated in the investigation. 21 suffered from psoriasis, 26 from chronic eczema and 24 from neurodermatitis. The duration of treatment was 2--3 weeks. The results show that the daily interval therapy is equivalent to the conventional mode of application and that both treatment methods were superior to the weekly interval therapy. Therapy was stopped in 2 patients of the weekly interval therapy-group and in one patient of the daily interval-group because of insufficient effect. Intolerance reactions were noticed in one patient of the conventional therapy group. The interval therapy leads--as expected--to a reduction of side reactions and to lessening of the corticosteroid amount applied.