Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1981;57(1):71-4.
doi: 10.1007/BF00271171.

Duplication deficiency as the result of meiotic segregation of a maternal InV (10)

E Yunis, O Torres de Caballero
Case Reports

Duplication deficiency as the result of meiotic segregation of a maternal InV (10)

E Yunis et al. Hum Genet. 1981.

Abstract

In a family a large pericentric inversion involving nearly 70% of the chromosome 10 has been segregating during three generations, giving several carriers and an affected male with the karyotype 46,XY,der(10)(10pter Leads to 10q25::10p12 Leads to 10pter)mat. The patient is trisomic for 10p except for a small segment near the centromere, and monosomic for the distal 10q26. A simple diagrammatic representation explains the behavior of the inv(10) in meiosis. The study of meiotic segregation in the present case, and the reviews of previously reported duplication-deficiencies, agree with established postulates and add some principles to the understanding of duplication deficiencies resulting from the meiotic behavior of inverted chromosomes.

PubMed Disclaimer

References

    1. Clin Genet. 1979 Mar;15(3):259-66 - PubMed
    1. Hum Genet. 1978 Feb 16;40(3):241-8 - PubMed
    1. Ann Genet. 1974 Jun;17 (2):115-8 - PubMed
    1. Ann Hum Genet. 1973 Apr;36(4):375-9 - PubMed
    1. Hum Genet. 1978 Mar 17;41(2):235-41 - PubMed

Publication types