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. 1981;51(1-2):107-11.
doi: 10.1007/BF01664008.

The effects of lisuride and some other dopaminergic agonists on receptor binding in human brain

G P Reynolds, P Riederer

The effects of lisuride and some other dopaminergic agonists on receptor binding in human brain

G P Reynolds et al. J Neural Transm. 1981.

Abstract

The effect of lisuride, bromocriptine, CQ 32-084 and CU 32-085 on the specific binding of radiolabelled spiperone to homogenates of human putamen taken post-mortem has been investigated. In addition, the binding of 3H-lisuride to such preparations has been studied. Lisuride is found to inhibit spiperone binding to the dopamine receptor at very low concentrations and to bind to the beta-adrenergic receptor at somewhat higher levels. Lisuride binding to the dopamine receptor was found to be antagonist-like. A measure of the in vivo effect of lisuride was obtained from investigations of brain tissue taken from a patient treated with the drug before death.

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