Identification and determination of tele-methylhistamine in cerebrospinal fluid by gas chromatography-mass spectrometry
- PMID: 7264669
- DOI: 10.1111/j.1471-4159.1981.tb00478.x
Identification and determination of tele-methylhistamine in cerebrospinal fluid by gas chromatography-mass spectrometry
Abstract
The presence of tele-methylhistamine in human cerebrospinal fluid has been established. The concentration was determined with the use of deuterated tele-methylhistamine. The preparation of the deuterated standard is described. The concentration range in samples from neuropsychiatric patients was 0.1--2.5 ng/ml. The structure of the pentafluoropropionyl derivative used for gas chromatography was studied with the aid of proton nuclear magnetic resonance spectroscopy.
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