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. 1981 Aug;6(1):39-43.
doi: 10.1016/0160-5402(81)90082-6.

Schultz-Dale reaction in mouse trachea

G A Koppel, K D Haisch, S M Spaethe, J R Schmidtke, J H Fleisch

Schultz-Dale reaction in mouse trachea

G A Koppel et al. J Pharmacol Methods. 1981 Aug.

Abstract

A method was developed to induce contraction of immunologically sensitized mouse trachea by antigen (Schultz-Dale reaction). The response was mediated by immunoglobulin (Ig) E antibody directed against either the hapten DNP, the hapten carrier conjugate DNP-keyhole limpet hemocyanin (KLH), or the unmodified carrier KLH. Tracheal contractions were elicited by DNP-KLH, KLH, or DNP-bovine serum albumin (BSA) but not by DNP or BSA alone. This procedure represents a useful index of in vitro anaphylaxis in mouse airway smooth muscle.

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