[Morphology and cytodynamics of oxazolone-induced cellular immune response]

Abstract

Dynamics of lymphoid tissue changes induced by oxazolone, a contact allergen responsible for immune reaction of delayed type was studied. Basing on light-and electron microscopic findings and morphometrical analysis the following components of the reaction may be distinguished: an early active lymphocytic migration, a delayed paracortex proliferation and a following follicular response. In the regulation of the outflow of lymphocytes a primary role may be attributed to the endothelial lining of the postcapillary venules. For the morphological changes of endothelial cells an effect of circulating antigen specific lymphocytes may be responsible.