Mutation-rate determinations based on electrophoretic analysis of laboratory mice

Abstract

Rate calculations are described for germinal mutations detected by an electrophoretic system as applied to mice in a series of recent experiments. The utility of the electrophoretic system is examined from several comparative viewpoints. The electrophoretic approach has a number of features to recommend it for future applications concerned with genetic hazard assessment. Its advantages include sensitivity, versatility, cost effectiveness and relevance to humans.