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. 1981 Mar;86(2):217-29.
doi: 10.1016/0165-1110(81)90026-9.

International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC working paper 2/3: carcinogens and carcinogenesis enhancers

D B Clayson

International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC working paper 2/3: carcinogens and carcinogenesis enhancers

D B Clayson. Mutat Res. 1981 Mar.

Abstract

The concept that chemical agents may lead to enhancement of carcinogenesis, rather than to its complete induction, is explored to explain the inexact correlation between carcinogen prescreening tests and the results of whole animal bioassays. It is suggested that carcinogenesis-enhancing agents are non-genotoxic chemicals which are positive in animal carcinogenesis bioassays. The importance of understanding the mechanisms of action of carcinogenesis-enhancing agents is emphasized.

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