Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1981 Apr;6(4):413-24.
doi: 10.1007/BF00963856.

Clozapine inhibition of metenkephalin binding to synaptosome-enriched fractions of rat whole brain and hippocampus

E Somoza, C Franco, M Laviña, J A Fuentes
Comparative Study

Clozapine inhibition of metenkephalin binding to synaptosome-enriched fractions of rat whole brain and hippocampus

E Somoza et al. Neurochem Res. 1981 Apr.

Abstract

Clozapine has been found to inhibit the binding of [3H]met-enkephalin to synaptosome-enriched fractions prepared from rat whole brain and hippocampus in a Tris-buffered media without added ions. The IC50 value for hippocampus is 28.5 microM. The inhibition constant for whole brain (41.0 microM) was found to be slightly larger than the corresponding value for chlorpromazine, which was measured under similar experimental conditions.

PubMed Disclaimer

References

    1. Annu Rev Neurosci. 1979;2:35-64 - PubMed
    1. Neuroscience. 1979;4(12):1883-93 - PubMed
    1. J Anat. 1962 Jan;96:79-88 - PubMed
    1. Neuropharmacology. 1978 Aug;17(8):577-81 - PubMed
    1. Nature. 1979 Jan 11;277(5692):93-6 - PubMed

Publication types

LinkOut - more resources