Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1980 Nov;56(661):783-4.
doi: 10.1136/pgmj.56.661.783.

Lithium toxicity induced by triamterene-hydrochlorothiazide

B R Mehta, B H Robinson
Case Reports

Lithium toxicity induced by triamterene-hydrochlorothiazide

B R Mehta et al. Postgrad Med J. 1980 Nov.

Abstract

Two patients on long-term lithium therapy for manic-depressive psychosis developed serious toxicity within days of being prescribed a combination of triamterene (50 mg) and hydrochlorothiazide (25 mg) for mild symptomless hypertension. Reduced clearance of lithium has been reported to follow its concurrent administration with diuretics that deplete both sodium and potassium. A combination of triamterene with thiazide has not been shown previously to precipitate lithium toxicity.

PubMed Disclaimer

References

    1. Lancet. 1970 Jan 24;1(7639):197-8 - PubMed
    1. JAMA. 1970 Nov 16;214(7):1325-6 - PubMed
    1. Br Med J. 1974 Jul 20;3(5924):143-5 - PubMed
    1. Br Med J. 1975 Mar 1;1(5956):516 - PubMed
    1. Am J Psychiatry. 1977 Feb;134(2):149-52 - PubMed

Publication types