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. 1981 Aug 28;213(4511):1034-6.
doi: 10.1126/science.7268407.

Hyperthermia-induced seizures in the rat pup: a model for febrile convulsions in children

D Holtzman, K Obana, J Olson

Hyperthermia-induced seizures in the rat pup: a model for febrile convulsions in children

D Holtzman et al. Science. .

Abstract

Seizures were produced in rat pups by ambient hyperthermia. Seizure threshold temperatures, measured rectally and intracerebrally, increased between 2 and 10 days of age. Electrocortical paroxysmal discharges were confirmed in hyperthermic 6- and 10-day-old pups. The increasing resistance to hyperthermic seizures with maturation and the electroencephalographic changes induced by hyperthermia are similar to those in young children.

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