[Investigations on the dependency of hemagglutination inhibition titers against rubella virus on the number and quality of antibody molecules (author's transl)]

Abstract

The number (A) and quality (K) of rubella virus antibody molecules has been determined for human sera obtained at graded time intervals after rubella infection or vaccination. Tests were carried out by use of a previously described technique (9) and the results were compared with the rubella HI titers found. Sera obtained within 59 days after onset of rash or vaccination of previously seronegative persons were found to contain antibody molecules of lower quality than did sera obtained at later time intervals. Sera obtained after vaccination of seronegative humans contained much smaller numbers of antibody molecules than did sera obtained after rubella infection. With the exception of sera obtained within 59 days after onset of rash, no significant differences in the number of antibody molecules per HI unit were found. The HI titers depended with this exception primarily on the number and not on the quality of antibody.