Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Apr;34(4):359-66.
doi: 10.7164/antibiotics.34.359.

Studies on neplanocin A, new antitumor antibiotic. I. Producing organism, isolation and characterization

S Yaginuma, N Muto, M Tsujino, Y Sudate, M Hayashi, M Otani
Free article

Studies on neplanocin A, new antitumor antibiotic. I. Producing organism, isolation and characterization

S Yaginuma et al. J Antibiot (Tokyo). 1981 Apr.
Free article

Abstract

Neplanocin A. C11H13N5O3, is a novel carbocyclic analog of adenosine with cyclopentene. It was isolated from the culture filtrate of Ampullariella regularis A11079 by means of ion-exchange, carbon, silica gel adsorption, or partition chromatography. Neplanocin A forms crystals, and is stable at acidic or alkaline pH. Neplanocin A has cytotoxicity against L5178Y cells in culture and showed a remarkable effect on the life prolongation of mice infected with L1210 leukemia.

PubMed Disclaimer

MeSH terms