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. 1978 Nov;14(5):723-6.
doi: 10.1128/AAC.14.5.723.

Penetration of methicillin, oxacillin, and cephalothin into bone and synovial tissues

R H Fitzgerald Jr, P J Kelly, R J Snyder, J A Washington 2nd

Penetration of methicillin, oxacillin, and cephalothin into bone and synovial tissues

R H Fitzgerald Jr et al. Antimicrob Agents Chemother. 1978 Nov.

Abstract

The penetrations of methicillin, oxacillin, and cephalothin into cortical bone and synovial tissues were studied 1 h after their intravenous administration in 105 patients having arthroplasty of the hip. Although the lowest serum levels were noted with cephalothin (P < 0.01), more patients receiving cephalothin achieved osseous drug levels inhibitory to staphylococci (P < 0.01). Differences in the penetration of the three agents into synovial tissues were not statistically significant.

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References

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