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. 1981 Oct 9;214(4517):200-2.
doi: 10.1126/science.7280691.

Sulfhydryl compounds may mediate gastric cytoprotection

S Szabo, J S Trier, P W Frankel

Sulfhydryl compounds may mediate gastric cytoprotection

S Szabo et al. Science. .

Abstract

Ethanol induces hemorrhagic gastric erosions and causes a dose-dependent decrease in the concentration of nonprotein sulfhydryl compounds in rat gastric mucosa. Sulfhydryl-containing drugs protect rats from ethanol-induced gastric erosions, whereas sulfhydryl blocking agents counteract the mucosal cytoprotective effect of prostaglandin F2 beta. These observations suggest that endogenous nonprotein sulfhydryls may mediate prostaglandin-induced gastric cytoprotection and that sulfhydryl drugs may have potential for preventing or treating hemorrhagic gastric erosions.

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