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. 1978 Oct 15;176(1):335-8.
doi: 10.1042/bj1760335.

Evidence for the participation of aspartate aminotransferase in hepatic glucose synthesis in the suckling newborn rat

P Ferré, D H Williamson

Evidence for the participation of aspartate aminotransferase in hepatic glucose synthesis in the suckling newborn rat

P Ferré et al. Biochem J. .

Abstract

Inhibition of liver aspartate aminotransferase by L-2-amino-4-methoxy-trans-3-butenoic acid in the suckling newborn rat causes a decrease in all gluconeogenic precursors from phosphoenolpyruvate to glucose and an accumulation of lactate but not of pyruvate. This suggests that the aspartate shuttle is operative and confirms the quantitative importance of lactate as a gluconeogenic precursor at this time during development.

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