[Lipids of blood and blood vessel wall in rabbits of various age with renal hypertension under conditions of experimental atherosclerosis]

Abstract

Patterns of lipid and lipoprotein turnover were examined in blood and aorta of 6-10 months old and 4-4.5 years old rabbits with the renal form of experimental hypertension, experimental atherosclerosis and combination of both pathological states. In experimental hypertension contents of the total fraction of low and very low density lipoproteins, total cholesterol and triglycerides were increased but the total lipolytic activity of postheparin blood plasma as well as a fraction of alpha-lipoprotein cholesterol in the total cholesterol were decreased both in young and old animals. experimental atherosclerosis in rabbits of various age with normal and elevated blood pressure was accompanied by the highest level of hyperlipidemia in old animals without distinct differences between rabbits with various initial arterial blood pressure. Deposition of lipids in aorta, which was observed in the animals with elevated arterial blood pressure after additional administration of cholesterol, was especially characteristic for old animals with experimental renal hypertension.