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. 1978 Dec;6(6):525-8.
doi: 10.1111/j.1365-2125.1978.tb00877.x.

The features of hepatic enzyme induction with glutethimide in man

L Jackson, M Homeida, C J Roberts

The features of hepatic enzyme induction with glutethimide in man

L Jackson et al. Br J Clin Pharmacol. 1978 Dec.

Abstract

1 Sequential measurements of D-glucaric acid excretion were made in six healthy volunteers before, during and after 3 weeks' daily medication with glutethimide 500 mg. 2 There was a rapid rise in D-glucaric acid excretion within 2 days of starting medication and a rapid decline when it was stopped. 3 Antipyrine clearance and indocyanine green clearance were measured before and at the end of the 3 weeks' medication. 4 There was a 55% increase in antipyrine clearance but no change in indocyanine green clearance. 5 There was no correlation between antipyrine clearance and D-glucaric acid excretion. 6 Glutethimide causes rapid enzyme induction in man without concomitant rise in hepatic blood flow.

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References

    1. Schweiz Med Wochenschr. 1964 Feb 15;94:235-40 - PubMed
    1. Biochem J. 1963 Jan;86(1):77-86 - PubMed
    1. Clin Sci. 1961 Aug;21:43-57 - PubMed
    1. Br J Clin Pharmacol. 1977 Jun;4(3):261-5 - PubMed
    1. Br J Clin Pharmacol. 1976 Oct;3(5):907-13 - PubMed

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