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. 1981 Oct 1;48(7):1497-9.
doi: 10.1002/1097-0142(19811001)48:7<1497::aid-cncr2820480702>3.0.co;2-i.

Herpesvirus type 2 in adenocarcinoma of the uterine cervix: a possible association

J Menczer, O Yaron-Schiffer, S Leventon-Kriss, M Modan, B Modan

Herpesvirus type 2 in adenocarcinoma of the uterine cervix: a possible association

J Menczer et al. Cancer. .

Abstract

Sera from 16 Jewish patients with histologically confirmed adenocarcinoma of the uterine cervix (AUC) and 32 control subjects matched by age and ethnic origin were examined for herpesvirus type 1 (HSV-1) and type 2 (HSV-2) neutralizing antibodies. Titers were determined by means of the quantitative plaque reduction neutralization test on VERO cell monolayers, using HSV-1 strain VR3 and HSV-2 strain. Significantly increased levels of antibodies against both virus strains were found in the AUC patients as compared with the controls. The trends in the AUC series resembled those in a previous similar case-control study of squamous cell carcinoma of the uterine cervix (SUC). Thus, the previously observed association between HSV-2 and SUC is true for AUC as well, despite differences in the clinical and epidemiologic characteristics of the two malignancies.

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