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Case Reports
. 1981 Sep;26(9):778-82.
doi: 10.1007/BF01309608.

Long-standing asymptomatic primary sclerosing cholangitis: report of three cases

R W Chapman, A K Burroughs, N M Bass, S Sherlock
Case Reports

Long-standing asymptomatic primary sclerosing cholangitis: report of three cases

R W Chapman et al. Dig Dis Sci. 1981 Sep.

Abstract

Three patients, two males and one female, with asymptomatic primary sclerosing cholangitis (PSC) are described. The diagnosis was made in each case by endoscopic retrograde cholangiography after investigation of persistent elevation of the serum alkaline phosphatase. All three have remained completely well without any medical or surgical treatment for 3, 7, and 15 years, respectively, despite extensive involvement of the biliary tree. Follow-up liver biopsies in two have shown no histological evidence of progression to secondary biliary cirrhosis. PSC may occur more frequently and may follow a less severe clinical course than previously recognized.

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