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Comparative Study
. 1981;20(3):233-4.
doi: 10.1007/BF00544604.

Acetylator phenotyping: a comparison of the isoniazid and dapsone tests

A Hanson, A Melander, E Wåhlin-Boll
Comparative Study

Acetylator phenotyping: a comparison of the isoniazid and dapsone tests

A Hanson et al. Eur J Clin Pharmacol. 1981.

Abstract

A comparison was made between the results of acetylator phenotyping by isoniazid (INH) half-life measurements based on 5 samples (0-6 h), and by determination of the ratio of monoacetylated (MAD) to unchanged dapsone (DDS) in a single sample obtained 3 h after dapsone intake. In each of 44 subjects examined, there was unequivocal agreement about classification of the subject as a rapid (INH t1/2 less than 2 h; MAD/DDS greater than 0.3) or slow (INH t1/2 greater than 2 h; MAD/DDS less than 0.3) acetylator. It appears that the single-sample (3 h) dapsone test is as reliable as the more laborious and time-consuming INH test for acetylator phenotyping.

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