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. 1981 Mar;17(3):275-83.
doi: 10.1111/j.1399-3011.1981.tb01993.x.

Amino acid composition and sequence of dermorphin, a novel opiate-like peptide from the skin of Phyllomedusa sauvagei

P C Montecucchi, R de Castiglione, S Piani, L Gozzini, V Erspamer

Amino acid composition and sequence of dermorphin, a novel opiate-like peptide from the skin of Phyllomedusa sauvagei

P C Montecucchi et al. Int J Pept Protein Res. 1981 Mar.

Abstract

Dermorphin, a heptapeptide with very potent opiate-like activity, has been isolated from methanol extracts of the skin of the South American frog Phyllomedusa sauvagei. The amino acid sequence of the peptide is: H-Try-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2. Dermorphin presents striking differences from the known enkephalins; it offers a surprising example of a peptide from Vertebrata containing a D-amino acid residue in its sequence.

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