Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Oct;68(4):1102-5.
doi: 10.1172/jci110334.

Collagen and collagen-derived fragments are chemotactic for tumor cells

G R Mundy, S DeMartino, D W Rowe

Collagen and collagen-derived fragments are chemotactic for tumor cells

G R Mundy et al. J Clin Invest. 1981 Oct.

Abstract

Organs that are rich in collagen such as liver, lungs, and bone are frequently sites of tumor cell metastasis. In this study, we have found that cultured tumor cells of human and rat origin migrated unidirectionally in response to collagen in vitro. Synthetic di- and tri-peptides that contained amino acid sequences found frequently in the collagen helix caused similar effects. These results are consistent with the hypothesis that collagen or collagen fragments released during connective tissue remodeling may be important in tumor cell metastasis.

PubMed Disclaimer

References

    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. Science. 1974 Mar;183(130):1200-1 - PubMed
    1. J Natl Cancer Inst. 1974 Sep;53(3):661-74 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Oct;72(10):4128-32 - PubMed
    1. J Exp Med. 1976 Jun 1;143(6):1299-307 - PubMed

Publication types