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. 1981 Jul;22(5):877-9.

Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride

P Kanda, M A Wells
  • PMID: 7288294
Free article

Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride

P Kanda et al. J Lipid Res. 1981 Jul.
Free article

Abstract

A simplified procedure for the synthesis of short acyl chain phosphatidylcholines is described. A mixed fatty acid-trifluoroacetic anhydride is used to acylate sn-glycero-3-phosphocholine (GPC) which has been dissolved in trifluoroacetic acid. Yields exceeding 70% are achieved in 30-min reaction time using 1.5 to 2.0 equivalents of mixed anhydride per, GPC hydroxyl. This allows a more economical use of labeled short chain acids.

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