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Case Reports
. 1981 Oct;126(4):544-5.
doi: 10.1016/s0022-5347(17)54619-4.

Uroepithelial carcinoma in association with cyclophosphamide ingestion

E F Fuchs, R Kay, R Poole, J M Barry, H D Pearse
Case Reports

Uroepithelial carcinoma in association with cyclophosphamide ingestion

E F Fuchs et al. J Urol. 1981 Oct.

Abstract

The association of daily oral cyclophosphamide with the development of transitional cell carcinoma or squamous cell carcinoma of the bladder had been documented. We report the first 2 cases of transitional cell carcinoma of the renal pelvis and an additional 4 cases of transitional cell carcinoma of the bladder following cyclophosphamide ingestion. Patients who have been taking daily oral cyclophosphamide for a prolonged period should have excretory urography, cystoscopy and bladder mucosal biopsies performed as part of a cancer surveillance protocol.

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