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. 1981 Oct 30;214(4520):558-9.
doi: 10.1126/science.7291992.

Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine

M Pollard, P H Luckert

Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine

M Pollard et al. Science. .

Abstract

Over the course of 20 weeks, Sprague-Dawley rats developed intestinal tumors in response to an intraperitoneal injection of the acetate derivative of dimethylnitrosamine. The same agent did not induce tumors in Lobund-Wistar rats. The number of tumors was significantly smaller in rats given drinking water containing indomethacin (beginning 14 days after the injections) than in control rats given drug-free water.

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