[Effect of post-ischemic restoration of blood flow on neuron-glia-capillary interrelations]

Abstract

The results of the study have shown that the changes occurring in ischemia are reversible. These changes are: perivascular edema of the astrocytes, dilation of the pericaryon and the cisterns of the endoplasmic reticulum, various forms of chromatolysis, and some changes of the capillary endothelium. An increase of the number of direct contacts between the basal membrane of the capillaries and the astrocytes, oligodendrocytes, neurons and their axons was observed. Complexes characterized by direct contact of all the constituents of the neuron-glia-capillary system were encountered. Such complexes were most typical for the median layers of the cortex. The types of the neuroglia-capillary interrelations described can be regarded as evidences of increased activity of the transport through the hematoencephalic barrier after post-ischemic restoration of the circulation. The direct contacts between the neurons. The glia, and the capillaries point to a possibility of direct exchange between the microcirculatory system and the neurons during the post-ischemic restoration of the circulation.