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. 1981 Oct;44(4):567-71.
doi: 10.1038/bjc.1981.227.

Resistance to the cytocidal effects of adriamycin is an early phenotypic change induced during hepatocarcinogenesis

B I Carr, B A Laishes
Free PMC article

Resistance to the cytocidal effects of adriamycin is an early phenotypic change induced during hepatocarcinogenesis

B I Carr et al. Br J Cancer. 1981 Oct.
Free PMC article

Abstract

Resistance to the cytocidal action of Adriamycin (ADR) was induced in rat hepatocytes by incorporation of the carcinogen 2-acetylaminofluorene (AAF) into the rat diet. Using a quantitative assay in primary monolayer culture, it was demonstrated that resistance to ADR is an early phenotypic change that is induced during chemical carcinogenesis in the rat, and appears to be stable.

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