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. 1981 Nov;74(3):511-3.
doi: 10.1111/j.1476-5381.1981.tb10457.x.

Rapid reversal by naloxone of the chronic effects of morphine on rat liver and brain tryptophan metabolism

A A Badawy, M Evans

Rapid reversal by naloxone of the chronic effects of morphine on rat liver and brain tryptophan metabolism

A A Badawy et al. Br J Pharmacol. 1981 Nov.

Abstract

The chronic morphine-induced inhibition of rat liver tryptophan pyrrolase activity and the resultant increases in tryptophan availability to the brain and brain 5-hydroxytryptamine (5-HT) synthesis are reversed within 10 min after naloxone administration. The possible involvement of hepatic tryptophan metabolism in morphine dependence is briefly discussed.

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