Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Oct;34(1):171-6.
doi: 10.1128/iai.34.1.171-176.1981.

Effects of pneumolysin on human polymorphonuclear leukocytes and platelets

M K Johnson, D Boese-Marrazzo, W A Pierce Jr

Effects of pneumolysin on human polymorphonuclear leukocytes and platelets

M K Johnson et al. Infect Immun. 1981 Oct.

Abstract

Pneumolysin was bound by human polymorphonuclear leukocytes in a reaction which occurred very rapidly at 0 degrees C. Low concentrations of pneumolysin were found to stimulate leukocyte migration and lysosomal enzyme secretion. At increasing lysin levels, inhibition of spontaneous migration and chemotaxis, cell death, and lysis were observed. Pneumolysin was also found to lyse platelets and to activate serum to become chemotactic.

PubMed Disclaimer

References

    1. Exp Cell Res. 1966 Sep;43(2):319-31 - PubMed
    1. Am J Pathol. 1968 Apr;52(4):725-36 - PubMed
    1. J Infect Dis. 1972 Apr;125(4):353-9 - PubMed
    1. Infect Immun. 1972 Nov;6(5):755-60 - PubMed
    1. Am J Pathol. 1965 Sep;47:419-33 - PubMed

Publication types

LinkOut - more resources