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. 1980;15(6):325-33.

Plasma nomifensine concentration. Cardiological effects and clinical response

I M McIntyre, G D Burrows, T R Norman, P Dumovic, J Vohra
  • PMID: 7298263

Plasma nomifensine concentration. Cardiological effects and clinical response

I M McIntyre et al. Int Pharmacopsychiatry. 1980.

Abstract

Cardiological effects of nomifensine were studied in 10 endogenously depressed in-patients receiving up to 200 mg/day for 3 weeks. No significant cardiac effects were observed using His' bundle electrography and electrocardiography. 9 of the 10 patients showed a significant recovery from their depressive illness. Plasma nomifensine concentrations at day 22 were not correlated with clinical response, blood pressure, or electrocardiographic parameters. A negative correlation between A-H interval, in the His' bundle electrogram, and day 22 nomifensine concentration was observed.

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