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. 1978 Nov 16;44(3):333-8.
doi: 10.1007/BF00394298.

Organization in vitro of ovarian cells into testicular structures

M T Zenzes, U Wolf, W Engel

Organization in vitro of ovarian cells into testicular structures

M T Zenzes et al. Hum Genet. .

Abstract

While it has been shown previously (Zenzes et al., 1978; Ohno et al., 1978) that when dissociated testicular cells are exposed to anti H-Y antiserum in vitro they are prevented from reorganizing into testicular structures, forming ovarian follicular structures instead, the most conclusive evidence for the action of H-Y antigen would be the conversion of ovarian cells into testicular organization. Testing for H-Y antigen of the medium collected from cultivated testicular cells revealed a positive reaction. Dissociated ovarian cells of newborn rats cultivated in this medium reorganize into testicular structures. It is concluded that H-Y antigen is responsible for this histomorphologic change.

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