Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Nov;14(11):951-5.
doi: 10.1007/BF02616126.

The effect of donor age on the in vitro life span of cultured human arterial smooth-muscle cells

E L Bierman

The effect of donor age on the in vitro life span of cultured human arterial smooth-muscle cells

E L Bierman. In Vitro. 1978 Nov.

Abstract

The number of population doublings of cultured human arterial smooth-muscle cells decreased as a function of donor age (0.5 to 82 years). Cells from older donors also showed longer latent periods for outgrowth from explants. These results extend other comparable observations with human skin fibroblasts to another cell type, and may have relevance to the pathogenesis of atherosclerosis with aging in vivo.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3584-8 - PubMed
    1. Circ Res. 1974 Jul;35(1):136-50 - PubMed
    1. J Cell Biol. 1971 Jul;50(1):172-86 - PubMed
    1. Exp Mol Pathol. 1973 Apr;18(2):125-41 - PubMed
    1. Cell Tissue Res. 1977 Feb 14;177(4):503-22 - PubMed

Publication types