Morphology of neoplastic lesions in the clitoral and prepucial gland of the F334 rat

Abstract

Three hundred fifty-nine neoplasms of the prepucial and clitoral glands of F344 rats were reviewed to classify the different types of tumors in relation to the normal anatomy and histology of the glands. Most tumors originated from the acinar of ductal cells, while only one tumor could be found originating from the mesenchymal tissue. They were classified as adenomas, adenocarcinomas, papillomas, squamous cell or basal cell carcinomas, and mixed cell carcinomas with different structural formations. Only one tumor metastasized to the lung.