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. 1981 Nov;24(11):1348-53.
doi: 10.1021/jm00143a017.

Sulfur analogues of psychotomimetic agents. Monothio analogues of mescaline and isomescaline

P Jacob 3rd, A T Shulgin

Sulfur analogues of psychotomimetic agents. Monothio analogues of mescaline and isomescaline

P Jacob 3rd et al. J Med Chem. 1981 Nov.

Abstract

Two monothio analogues of mescaline and three monothio analogues of 2,3,4-trimethoxyphenethylamine (isomescaline) have been synthesized and characterized. Only the two mescaline analogues (3-and 4-thiomescaline) were found to be psychotomimetics in man, being 6 and 12 times more potent than mescaline, respectively. All five compounds can serve as substrates for bovine plasma monoamine oxidase in vitro, but no positive correlation is apparent between the extent of enzymatic degradation and human psychotomimetic potency.

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