Ultrastructure of pineal parenchymal neoplasms

Abstract

The fine structures of two pineal parenchymal neoplasms has been described. The tumors contained a predominance of small, poorly differentiated cells with prominent nuclei and scanty cytoplasm. These cells were similar to those found in medulloblastomas, primitive cerebral neuroectodermal tumors, and fetal cerebellum and cerebrum. Some cells contained 9 + 0 cilia, dense core vesicles, and processes containing microtubules and numerous dense core and clear vesicles, suggesting neuronal differentiation. Astrocytic elements were also present. This study suggests that the predominant cells of these tumors are primitive neuroectodermal elements which have the potential to differentiate along several different lines.